• Education and Experience:

    B.S. in Life Science
    Chung Shan Medical University, Taiwan
     
    M.S. in Molecular Medicine
    National Cheng Kung University, Taiwan
     
    Ph.D. in Molecular Biology
    University of Colorado Denver, Anschutz Medical Campus, USA
     
    Postdoctoral Fellow
    Department of Pharmacology, University of Colorado Denver, Anschutz Medical Campus, USA
     
    Postdoctoral Fellow
    The Institute of Basic Medical Science
    National Cheng Kung University, Taiwan
     
    Assistant Professor (2022-present), The Institute of Basic Medical Science (full-time), Department of Physiology (adjunct),
    National Cheng Kung University, Taiwan

    Research Interest

    1. Pancreatic cancer biology 胰臟癌發展之機制探討
    2. Function and regulation of extracellular vesicle in cancer progression 胞外體在癌症發展中之角色探討
    3. Tumor-associated lymph-angiogenesis 淋巴血管新生於腫瘤發展之功能與調控

    Publications

    1. Chu-An Wang, Chien-Feng Li, Rho-Chi Huang, Yo-Hua Li, Jing-Ping Liou, Shaw-Jenq Tsai. Suppression of Extracellular Vesicle VEGF-C-mediated Lymphangiogenesis and Pancreatic Cancer Early Dissemination By a Selective HDAC1/2 Inhibitor. Mol Cancer Ther. 2021 Sep;20(9):1550-1560.
    2. Wei-Che Tseng, Chi-Yuan Chen, Ching-Yuh Chern, Chu-An Wang, Wen-Chih Lee, Ying-Chih Chi, Shu-Fang Cheng, Yi-Tsen Kuo, Ya-Chen Chiu, Shih-Ting Tseng, Pei-Ya Lin, Shou-Jhen Liou, Yi-Chen Li, Chin-Chuan Chen. Targeting HR Repair as a Synthetic Lethal Approach to Increase DNA Damage Sensitivity by a RAD52 Inhibitor in BRCA2-Deficient Cancer Cells. Int J Mol Sci. 2021 Apr 23;22(9):4422.
    3. Wang CA and Shaw-Jenq Tsai. Regulation of lymphangiogenesis by extracellular vesicles in cancer metastasis. Exp Biol Med (Maywood). 2021 Jun 18;15353702211021022.
    4. Wan-Ning Li, Kuei-Yang Hsiao, Chu-An Wang, Ning Chang, Pei-Ling Hsu, Chung-Hsien Sun, Shang-Rung Wu, Meng-Hsing Wu, Shaw-Jenq Tsai. Extracellular vesicle-associated VEGF-C promotes lymphangiogenesis and immune cells infiltration in endometriosis. PNAS October 13, 2020 117 (41) 25859-25868
    5. Chu-An Wang , Yi-Hern Chang , Pei-Chi Hou , Yu-Jing Tai , Wan-Ning Li, Pei-Ling Hsu, ShangRung Wu, Wen-Tai Chiu, Chien-Feng Li , Yan-Shen Shan , Shaw-Jenq Tsai. DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination. J Extracell Vesicles. 2020 Apr 4;9(1):1746529.
    6. Towers CG, Guarnieri AL, Micalizzi DS, Harrell JC, Gillen AE, Kim J, Wang CA, Oliphant MU, Drasin DJ, Guney MA, Kabos P, Sartorius CA, Tan AC, Perou CM, Espinosa JM, Ford HL. The Six1 oncoprotein represses translation of p53 via concomitant regulation of RPL26 and microRNA-27a. Nat Commun. 2015 Dec 21;6:10077.
    7. Wang CA and Shaw-Jenq Tsai. The non-canonical role of vascular endothelial growth factor-C axis in cancer progression. Exp Biol Med (Maywood). 2015 Jun;240(6):718-24.
    8. David J. Drasin , Anna L. Guarnieri , Deepika Neelakantan , Jihye Kim , Joshua H. Cabrera , Chu-An Wang , Vadym Zaberezhnyy , Pierluigi Gasparini , Luciano Cascione , Kay Huebner , Aik Choon Tan, Ford HL. TWIST1-induced microRNA-424 reversibly drives mesenchymal programming while inhibiting tumor initiation. Cancer Res. 2015 May 1;75(9):1908-21
    9. Wang CA, Drasin DJ, Pham C, Jedlicka P, Zaberezhnyy V, Guney M, Li H, Nemenoff R, Costello J, Tan AC, Ford HL. Homeoprotein Six2 Promotes Breast Cancer Metastasis via Transcriptional and Epigenetic Control of E-Cadherin Expression. Cancer Res. 2014 Dec 15;74(24):7357-70.
    10. Wang CA, Harrell J, Iwanaga R, Jedlicka P, Ford HL. Vascular endothelial growth factor-C promotes breast cancer progression via a novel anti-oxidant mechanism that involves regulation of Superoxide dismutase 3. Breast Cancer Res. 2014 Oct 30;16(5):462.
    11. Ritsuko Iwanaga, Chu-An Wang, Douglas S. Micalizzi, Chuck J. Harrell, Paul Jedlicka, Carol Sartorius, Peter Kabos, Andrew P Bradford, Heide L. Ford. Six1 enhances tumor initiating cell activity and predicts poor prognosis in luminal breast cancers. Breast Cancer Res. 2012 Jul 5;14(4):R100.
    12. Wang CA, Jedlicka P, Patrick AN, Micalizzi DS, Lemmer KC, Deitsch E, Casás-Selves M, Harrell JC, Ford HL. SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer. J Clin Invest. 2012 May 1;122(5):1895-906. Research was highlighted as a short article at: Metastasis: SIX1 of the best. Nat Rev Cancer. 2012 May 24;12(5):316.
    13. Micalizzi DS, Wang CA, Farabaugh SM, Schiemann WP, Ford HL. Homeoprotein Six1 increases TGF-beta type I receptor and converts TGF-beta signaling from suppressive to supportive for tumor growth. Cancer Res. 2010 Dec 15;70(24):10371-80.
    14. W. Chen,S.-J. Tsai, C.-A. Wang, J.-C. Tsai, C.C. Zouboulis. Human sebocytes express prostaglandin E2 receptors EP2 and EP4 but treatment with prostaglandin E2 does not affect testosterone production. Br J Dermatol. 2009 Sep;161(3):674-7.
    15. Meng-Hsing Wu,* Chu-An Wang,* Chen-Chung Lin, Lei-Chin Chen, Wen-Chang Chang, and ShawJenq Tsai. Distinct regulation of cyclooxygenase-2 by interleukin-1beta in normal and endometriotic stromal cells. J Clin Endocrinol Metab. 2005 Jan;90(1):286-95. (equal contribution first author)
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